There is no definitive answer to this question as it depends on a number of factors, including the applicant's academic record, test scores, and personal qualifications. However, some California State Universities (CSUs) are generally considered more competitive than others. For example, CSU Los Angeles and CSU San Bernardino typically have lower acceptance rates than other CSUs. Additionally, the most popular majors at some CSUs (such as business and engineering) may be more difficult to get into due to the high demand for these programs. Ultimately, it is important to research each individual CSU's admissions requirements and process in order to determine which one may be the most difficult for you to get into.